Detailed information of TA system TA025777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3826916..3827429
• Replicon: chromosome
• Accession: NC_016629
• Organism: Desulfovibrio africanus str. Walvis Bay

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F3YXH5
• Locus tag: DESAF_RS17375
• Protein ID: WP_014261366.1
• Coordinates: 3827145..3827429 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DESAF_RS17370
• Protein ID: WP_041281515.1
• Coordinates: 3826916..3827155 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DESAF_RS17350	3823781..3824482	-	702	WP_014261361.1	porin family protein	-
DESAF_RS17355	3825373..3826008	+	636	WP_014261362.1	LysE family translocator	-
DESAF_RS17360	3826136..3826417	+	282	WP_014261363.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DESAF_RS17365	3826428..3826736	+	309	WP_014261364.1	HigA family addiction module antidote protein	-
DESAF_RS17370	3826916..3827155	+	240	WP_041281515.1	ribbon-helix-helix protein, CopG family	Antitoxin
DESAF_RS17375	3827145..3827429	+	285	WP_014261366.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DESAF_RS17380	3827609..3828244	+	636	WP_014261367.1	TetR/AcrR family transcriptional regulator	-
DESAF_RS17385	3828310..3829287	+	978	WP_144082464.1	TRAP transporter substrate-binding protein	-
DESAF_RS17390	3829489..3829995	+	507	WP_014261369.1	TRAP transporter small permease	-
DESAF_RS17395	3829995..3831308	+	1314	WP_014261370.1	TRAP transporter large permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10903.57 Da
• Isoelectric Point: 11.6386

>T25777 WP_014261366.1 NC_016629:3827145-3827429 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
MPARPVRWLRQALRDMDEIATFIAMDDPRTARDVAGRIWEAAGTLGQSPERGRIGRVPGTREPVLPNLPYFLAYRVREGE
VQILRVIHQRRQRE

Nucleotide

• Length: 285 bp

>T25777 NC_016629:3827145-3827429 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
ATGCCGGCTAGGCCGGTGCGCTGGCTGCGTCAGGCCTTGCGCGACATGGACGAAATCGCCACCTTCATCGCCATGGATGA
TCCGCGCACGGCCCGTGATGTGGCCGGCCGCATCTGGGAGGCGGCCGGAACGCTTGGCCAATCGCCGGAACGGGGGCGGA
TCGGGCGAGTGCCCGGAACCAGGGAACCGGTCCTGCCCAACTTGCCGTATTTCCTGGCCTACCGCGTGCGAGAGGGCGAG
GTGCAGATCCTGCGTGTCATCCATCAGCGTCGGCAGCGGGAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8740.63 Da
• Isoelectric Point: 4.2584

>AT25777 WP_041281515.1 NC_016629:3826916-3827155 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
MPTVTTRLDNETQAKLEALAKATDRSRSWLVADAIRRYVEEESWQVAAIEEGVRQADAGDFASDEEVKQAFAKLDVNAG

Nucleotide

• Length: 240 bp

>AT25777 NC_016629:3826916-3827155 [Desulfocurvibacter africanus subsp. africanus str. Walvis Bay]
ATGCCCACAGTGACGACCAGGCTGGATAACGAAACCCAAGCCAAGCTCGAGGCCTTGGCCAAGGCTACGGACCGCTCCCG
CTCGTGGCTGGTGGCCGACGCGATCCGGCGCTATGTCGAGGAGGAAAGCTGGCAGGTTGCCGCCATAGAAGAAGGAGTCC
GGCAGGCCGATGCCGGGGATTTCGCTTCGGACGAAGAGGTGAAGCAGGCCTTTGCCAAGTTGGACGTGAATGCCGGCTAG

Structures

Toxin

• AlphaFold DB: F3YXH5