Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4185494..4186275 Replicon chromosome
Accession NZ_CP104358
Organism Salmonella enterica strain PNUSAS119065

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag N4275_RS20470 Protein ID WP_000626100.1
Coordinates 4185494..4185985 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag N4275_RS20475 Protein ID WP_001110452.1
Coordinates 4185982..4186275 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4275_RS20435 (4180954) 4180954..4181301 + 348 WP_050953799.1 divalent cation tolerance protein CutA -
N4275_RS20440 (4181277) 4181277..4182980 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
N4275_RS20445 (4183017) 4183017..4183592 + 576 WP_001188509.1 transcriptional regulator -
N4275_RS20455 (4183863) 4183863..4183937 - 75 Protein_3997 helix-turn-helix domain-containing protein -
N4275_RS20460 (4184317) 4184317..4184394 + 78 Protein_3998 porin family protein -
N4275_RS20465 (4184494) 4184494..4185246 + 753 WP_000842433.1 non-specific acid phosphatase -
N4275_RS20470 (4185494) 4185494..4185985 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
N4275_RS20475 (4185982) 4185982..4186275 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
N4275_RS20480 (4186592) 4186592..4186813 + 222 WP_001576552.1 hypothetical protein -
N4275_RS20485 (4187079) 4187079..4187954 + 876 WP_000921676.1 AraC family transcriptional regulator -
N4275_RS20490 (4187951) 4187951..4188238 + 288 WP_001541332.1 transcriptional regulator RtsB -
N4275_RS20495 (4188231) 4188231..4188413 - 183 WP_001676222.1 ATP-binding cassette domain-containing protein -
N4275_RS20500 (4188538) 4188538..4188786 + 249 Protein_4006 Ig-like domain-containing protein -
N4275_RS20505 (4188898) 4188898..4189029 + 132 Protein_4007 hypothetical protein -
N4275_RS20510 (4189323) 4189323..4190228 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T257751 WP_000626100.1 NZ_CP104358:c4185985-4185494 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT257751 WP_001110452.1 NZ_CP104358:c4186275-4185982 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References