Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3987221..3987797 Replicon chromosome
Accession NZ_CP104358
Organism Salmonella enterica strain PNUSAS119065

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N4275_RS19455 Protein ID WP_001131963.1
Coordinates 3987510..3987797 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag N4275_RS19450 Protein ID WP_000063142.1
Coordinates 3987221..3987523 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4275_RS19435 (3983731) 3983731..3985881 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
N4275_RS19440 (3985976) 3985976..3986179 + 204 WP_000460616.1 YbdD/YjiX family protein -
N4275_RS19445 (3986190) 3986190..3987146 + 957 WP_000187843.1 GTPase -
N4275_RS19450 (3987221) 3987221..3987523 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
N4275_RS19455 (3987510) 3987510..3987797 - 288 WP_001131963.1 BrnT family toxin Toxin
N4275_RS19460 (3988207) 3988207..3990048 + 1842 WP_000974636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
N4275_RS19465 (3990661) 3990661..3991236 + 576 WP_000593784.1 restriction endonuclease subunit S -
N4275_RS19470 (3991241) 3991241..3992494 + 1254 WP_001206755.1 N-6 DNA methylase -
N4275_RS19475 (3992526) 3992526..3992660 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T257748 WP_001131963.1 NZ_CP104358:c3987797-3987510 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT257748 WP_000063142.1 NZ_CP104358:c3987523-3987221 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References