Detailed information of TA system TA025773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 5140..5668
• Replicon: chromosome
• Accession: NC_016628
• Organism: Vibrio furnissii NCTC 11218

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K5TRR0
• Locus tag: VFU_RS15415
• Protein ID: WP_005377002.1
• Coordinates: 5140..5430 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: VFU_RS15420
• Protein ID: WP_041943099.1
• Coordinates: 5420..5668 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VFU_RS23870	1342..1485	+	144	Protein_1	DUF3265 domain-containing protein	-
VFU_RS15400	1501..2640	+	1140	WP_193386114.1	NgoFVII family restriction endonuclease	-
VFU_RS23090	2665..2757	+	93	WP_079857966.1	DUF3265 domain-containing protein	-
VFU_RS23095	3474..3617	+	144	WP_014257151.1	DUF3265 domain-containing protein	-
VFU_RS15410	3610..4164	+	555	Protein_5	V3/V1b-type arginine vasotocin receptor	-
VFU_RS23100	4179..4271	+	93	WP_074534780.1	DUF3265 domain-containing protein	-
VFU_RS23110	5010..5219	+	210	WP_081454223.1	DUF3265 domain-containing protein	-
VFU_RS15415	5140..5430	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VFU_RS15420	5420..5668	-	249	WP_041943099.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VFU_RS23120	6149..6298	+	150	WP_081454265.1	DUF3265 domain-containing protein	-
VFU_RS15425	6308..6733	+	426	WP_041943101.1	N-acetyltransferase	-
VFU_RS15430	6885..7622	+	738	WP_014257156.1	SDR family oxidoreductase	-
VFU_RS15435	7860..8216	+	357	WP_041943103.1	hypothetical protein	-
VFU_RS15440	8304..8519	+	216	WP_041943105.1	hypothetical protein	-
VFU_RS15445	8692..9213	+	522	WP_041943107.1	GNAT family N-acetyltransferase	-
VFU_RS15450	9343..10266	+	924	WP_014257157.1	arginase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / htpB / hcp-2 / vgrG-2 / hlyA / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasJ / icmF/vasK	3..1621672	1621669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11261.25 Da
• Isoelectric Point: 10.5932

>T25773 WP_005377002.1 NC_016628:c5430-5140 [Vibrio furnissii NCTC 11218]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T25773 NC_016628:c5430-5140 [Vibrio furnissii NCTC 11218]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTGGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AACTCCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9093.39 Da
• Isoelectric Point: 3.9610

>AT25773 WP_041943099.1 NC_016628:c5668-5420 [Vibrio furnissii NCTC 11218]
MTTRILADVAASITELKANPMKVATSAYGEPVAILNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT25773 NC_016628:c5668-5420 [Vibrio furnissii NCTC 11218]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTATACTGAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCAGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATTGCGAAAGAGCGTGAATCTGAAGAGAGTATTTCGGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A347UR03