257717

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 648437..649203 Replicon chromosome
Accession NZ_CP104355
Organism Vibrio cholerae strain PNUSAV001140

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag N4267_RS16770 Protein ID WP_000982260.1
Coordinates 648437..648934 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag N4267_RS16775 Protein ID WP_134987530.1
Coordinates 648931..649203 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4267_RS16715 (N4267_16715) 643447..644226 + 780 WP_001887508.1 NYN domain-containing protein -
N4267_RS16720 (N4267_16720) 644557..644674 + 118 Protein_647 DUF645 family protein -
N4267_RS16725 (N4267_16725) 644924..645181 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
N4267_RS16730 (N4267_16730) 645169..645471 + 303 WP_033930520.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4267_RS16735 (N4267_16735) 645632..646120 + 489 WP_033933186.1 hypothetical protein -
N4267_RS16740 (N4267_16740) 646186..646352 + 167 Protein_651 acetyltransferase -
N4267_RS16745 (N4267_16745) 646413..646565 + 153 Protein_652 DUF645 family protein -
N4267_RS16750 (N4267_16750) 646772..647197 + 426 WP_061051384.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
N4267_RS16755 (N4267_16755) 647481..647756 + 276 WP_113629420.1 hypothetical protein -
N4267_RS16760 (N4267_16760) 647762..648247 + 486 WP_113629421.1 hypothetical protein -
N4267_RS16765 (N4267_16765) 648285..648404 + 120 WP_113629423.1 DUF3265 domain-containing protein -
N4267_RS16770 (N4267_16770) 648437..648934 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
N4267_RS16775 (N4267_16775) 648931..649203 - 273 WP_134987530.1 DUF1778 domain-containing protein Antitoxin
N4267_RS16780 (N4267_16780) 649355..649531 + 177 WP_134987531.1 acetyltransferase -
N4267_RS16785 (N4267_16785) 649620..649772 + 153 WP_175248612.1 DUF645 family protein -
N4267_RS16790 (N4267_16790) 649887..649985 + 99 WP_200894328.1 acetyltransferase -
N4267_RS16795 (N4267_16795) 650006..650272 + 267 WP_000589156.1 BrnT family toxin -
N4267_RS16800 (N4267_16800) 650259..650501 + 243 WP_033933251.1 hypothetical protein -
N4267_RS16805 (N4267_16805) 650654..651646 + 993 WP_170887264.1 hypothetical protein -
N4267_RS16810 (N4267_16810) 651669..652628 - 960 WP_134987445.1 IS30 family transposase -
N4267_RS16815 (N4267_16815) 653331..653867 + 537 WP_019281268.1 GNAT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 557944..665509 107565
- inside Integron - - 559057..664638 105581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T257717 WP_000982260.1 NZ_CP104355:c648934-648437 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9699.22 Da        Isoelectric Point: 6.2988

>AT257717 WP_134987530.1 NZ_CP104355:c649203-648931 [Vibrio cholerae]
MATTLPRITARVDIDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure

References