Detailed information of TA system TA257713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1144591..1146313
• Replicon: chromosome
• Accession: NZ_CP104354
• Organism: Vibrio cholerae strain PNUSAV001140

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: N4267_RS05390
• Protein ID: WP_001961076.1
• Coordinates: 1145375..1146313 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: N4267_RS05385
• Protein ID: WP_001896349.1
• Coordinates: 1144591..1145382 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4267_RS05350 (N4267_05350)	1139761..1140084	-	324	WP_001896384.1	type II toxin-antitoxin system RelE/ParE family toxin	-
N4267_RS05355 (N4267_05355)	1140265..1140546	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
N4267_RS05360 (N4267_05360)	1140543..1141169	+	627	WP_001896361.1	TraE/TraK family type IV conjugative transfer system protein	-
N4267_RS05365 (N4267_05365)	1141153..1142049	+	897	WP_001896336.1	type-F conjugative transfer system secretin TraK	-
N4267_RS05370 (N4267_05370)	1142052..1143341	+	1290	WP_134987188.1	TraB/VirB10 family protein	-
N4267_RS05375 (N4267_05375)	1143416..1143988	+	573	WP_147422779.1	type IV conjugative transfer system lipoprotein TraV	-
N4267_RS05380 (N4267_05380)	1143985..1144371	+	387	WP_001896311.1	TraA family conjugative transfer protein	-
N4267_RS05385 (N4267_05385)	1144591..1145382	+	792	WP_001896349.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
N4267_RS05390 (N4267_05390)	1145375..1146313	+	939	WP_001961076.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N4267_RS05395 (N4267_05395)	1146836..1147492	-	657	WP_001896334.1	hypothetical protein	-
N4267_RS05400 (N4267_05400)	1147536..1147682	-	147	WP_162838621.1	hypothetical protein	-
N4267_RS05405 (N4267_05405)	1147924..1148616	+	693	WP_001896353.1	DsbC family protein	-
N4267_RS05410 (N4267_05410)	1148616..1151015	+	2400	WP_001896378.1	type IV secretion system protein TraC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1124504..1229432	104928

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35562.89 Da
• Isoelectric Point: 5.0082

>T257713 WP_001961076.1 NZ_CP104354:1145375-1146313 [Vibrio cholerae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPKAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30099.46 Da
• Isoelectric Point: 9.5097

>AT257713 WP_001896349.1 NZ_CP104354:1144591-1145382 [Vibrio cholerae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp