257709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 185856..186444 Replicon plasmid unnamed1
Accession NZ_CP104352
Organism Acinetobacter baumannii strain 2021CK-01335

Toxin (Protein)


Gene name brnT Uniprot ID N8SM64
Locus tag N4T38_RS20915 Protein ID WP_000438825.1
Coordinates 185856..186143 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID D3JXQ4
Locus tag N4T38_RS20920 Protein ID WP_004728120.1
Coordinates 186130..186444 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T38_RS20895 (N4T38_20895) 182036..183228 + 1193 WP_085955245.1 IS3-like element ISKpn18 family transposase -
N4T38_RS20900 (N4T38_20900) 183347..183961 + 615 WP_125281634.1 recombinase family protein -
N4T38_RS20905 (N4T38_20905) 184027..184830 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
N4T38_RS20910 (N4T38_20910) 184830..185666 + 837 WP_040110386.1 APH(6)-I family aminoglycoside O-phosphotransferase -
N4T38_RS20915 (N4T38_20915) 185856..186143 + 288 WP_000438825.1 BrnT family toxin Toxin
N4T38_RS20920 (N4T38_20920) 186130..186444 + 315 WP_004728120.1 BrnA antitoxin family protein Antitoxin
N4T38_RS20925 (N4T38_20925) 186611..187054 - 444 WP_260744098.1 hypothetical protein -
N4T38_RS20930 (N4T38_20930) 187132..188100 + 969 WP_252513945.1 IS30 family transposase -
N4T38_RS20935 (N4T38_20935) 188302..188604 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T38_RS20940 (N4T38_20940) 188605..188886 + 282 WP_000985609.1 putative addiction module antidote protein -
N4T38_RS20945 (N4T38_20945) 188966..189385 - 420 WP_001180106.1 SMI1/KNR4 family protein -
N4T38_RS20950 (N4T38_20950) 189525..189845 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T38_RS20955 (N4T38_20955) 189838..190110 + 273 WP_000369781.1 NadS family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(X3) / sul2 / aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) / ARR-3 / qacE / sul1 / blaNDM-1 / aph(3')-VI / blaOXA-58 - 1..335718 335718
- inside IScluster/Tn aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) - 175189..193018 17829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11304.70 Da        Isoelectric Point: 5.6205

>T257709 WP_000438825.1 NZ_CP104352:185856-186143 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12200.86 Da        Isoelectric Point: 8.4628

>AT257709 WP_004728120.1 NZ_CP104352:186130-186444 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TVQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8TRI9

References