Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 477912..478565 Replicon chromosome
Accession NZ_CP104351
Organism Acinetobacter baumannii strain 2021CK-01335

Toxin (Protein)


Gene name cptA Uniprot ID A0A427QZH0
Locus tag N4T38_RS02345 Protein ID WP_000931891.1
Coordinates 478176..478565 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag N4T38_RS02340 Protein ID WP_001288210.1
Coordinates 477912..478169 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T38_RS02320 (N4T38_02320) 473427..474434 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
N4T38_RS02325 (N4T38_02325) 474453..474830 + 378 WP_001216380.1 50S ribosomal protein L17 -
N4T38_RS02330 (N4T38_02330) 475012..476502 + 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
N4T38_RS02335 (N4T38_02335) 476552..477724 - 1173 WP_001190558.1 acyl-CoA dehydrogenase family protein -
N4T38_RS02340 (N4T38_02340) 477912..478169 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
N4T38_RS02345 (N4T38_02345) 478176..478565 + 390 WP_000931891.1 hypothetical protein Toxin
N4T38_RS02350 (N4T38_02350) 479335..480420 + 1086 WP_000049104.1 hypothetical protein -
N4T38_RS02355 (N4T38_02355) 480498..481064 + 567 WP_000651536.1 rhombosortase -
N4T38_RS02360 (N4T38_02360) 481252..483447 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T257706 WP_000931891.1 NZ_CP104351:478176-478565 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT257706 WP_001288210.1 NZ_CP104351:477912-478169 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427QZH0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References