257694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 203604..204192 Replicon plasmid unnamed1
Accession NZ_CP104343
Organism Acinetobacter baumannii strain 2021CK-01300

Toxin (Protein)


Gene name brnT Uniprot ID N8SM64
Locus tag N4T35_RS21250 Protein ID WP_000438825.1
Coordinates 203905..204192 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID D3JXQ4
Locus tag N4T35_RS21245 Protein ID WP_004728120.1
Coordinates 203604..203918 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T35_RS21210 (N4T35_21210) 199938..200210 - 273 WP_000369781.1 NadS family protein -
N4T35_RS21215 (N4T35_21215) 200203..200523 - 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T35_RS21220 (N4T35_21220) 200663..201082 + 420 WP_001180106.1 SMI1/KNR4 family protein -
N4T35_RS21225 (N4T35_21225) 201162..201443 - 282 WP_000985609.1 putative addiction module antidote protein -
N4T35_RS21230 (N4T35_21230) 201444..201746 - 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T35_RS21235 (N4T35_21235) 201948..202916 - 969 WP_260785412.1 IS30 family transposase -
N4T35_RS21240 (N4T35_21240) 202994..203437 + 444 WP_260744098.1 hypothetical protein -
N4T35_RS21245 (N4T35_21245) 203604..203918 - 315 WP_004728120.1 BrnA antitoxin family protein Antitoxin
N4T35_RS21250 (N4T35_21250) 203905..204192 - 288 WP_000438825.1 BrnT family toxin Toxin
N4T35_RS21255 (N4T35_21255) 204382..205218 - 837 WP_040110386.1 APH(6)-I family aminoglycoside O-phosphotransferase -
N4T35_RS21260 (N4T35_21260) 205218..206021 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
N4T35_RS21265 (N4T35_21265) 206087..206701 - 615 WP_125281634.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 / aph(3')-VI / blaNDM-1 / sul1 / qacE / ARR-3 / mph(E) / msr(E) / aph(6)-Id / aph(3'')-Ib / sul2 / tet(X3) - 1..335718 335718
- inside IScluster/Tn mph(E) / msr(E) / aph(6)-Id / aph(3'')-Ib - 197030..214859 17829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11304.70 Da        Isoelectric Point: 5.6205

>T257694 WP_000438825.1 NZ_CP104343:c204192-203905 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12200.86 Da        Isoelectric Point: 8.4628

>AT257694 WP_004728120.1 NZ_CP104343:c203918-203604 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TVQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8TRI9

References