Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 776445..777098 Replicon chromosome
Accession NZ_CP104335
Organism Acinetobacter baumannii strain 2021CK-01408

Toxin (Protein)


Gene name cptA Uniprot ID A0A427QZH0
Locus tag N4T40_RS04080 Protein ID WP_000931891.1
Coordinates 776445..776834 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag N4T40_RS04085 Protein ID WP_001288210.1
Coordinates 776841..777098 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T40_RS04065 (N4T40_04065) 771563..773758 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
N4T40_RS04070 (N4T40_04070) 773946..774512 - 567 WP_000651536.1 rhombosortase -
N4T40_RS04075 (N4T40_04075) 774590..775675 - 1086 WP_000049104.1 hypothetical protein -
N4T40_RS04080 (N4T40_04080) 776445..776834 - 390 WP_000931891.1 hypothetical protein Toxin
N4T40_RS04085 (N4T40_04085) 776841..777098 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
N4T40_RS04090 (N4T40_04090) 777286..778458 + 1173 WP_001190558.1 acyl-CoA dehydrogenase family protein -
N4T40_RS04095 (N4T40_04095) 778508..779998 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
N4T40_RS04100 (N4T40_04100) 780180..780557 - 378 WP_001216380.1 50S ribosomal protein L17 -
N4T40_RS04105 (N4T40_04105) 780576..781583 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T257678 WP_000931891.1 NZ_CP104335:c776834-776445 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT257678 WP_001288210.1 NZ_CP104335:c777098-776841 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427QZH0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References