Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 46432..46954 Replicon plasmid pHB42-F3
Accession NZ_CP104331
Organism Escherichia coli strain THB42-F3

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N0544_RS22600 Protein ID WP_000220561.1
Coordinates 46673..46954 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N0544_RS22595 Protein ID WP_000121743.1
Coordinates 46432..46683 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0544_RS22575 (42555) 42555..42908 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
N0544_RS22580 (43045) 43045..43491 - 447 WP_001074384.1 hypothetical protein -
N0544_RS22585 (43495) 43495..44337 - 843 WP_000435064.1 replication initiation protein -
N0544_RS22590 (44358) 44358..45197 - 840 WP_024129959.1 replication initiation protein -
N0544_RS22595 (46432) 46432..46683 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N0544_RS22600 (46673) 46673..46954 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0544_RS22605 (47193) 47193..47285 - 93 Protein_48 IS6 family transposase -
N0544_RS22610 (47451) 47451..48650 - 1200 WP_000948429.1 IS91 family transposase -
N0544_RS22615 (48660) 48660..48848 - 189 WP_000957857.1 hypothetical protein -
N0544_RS22620 (48968) 48968..50398 + 1431 Protein_51 IS4-like element IS50R family transposase -
N0544_RS22625 (50427) 50427..51221 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
N0544_RS22630 (51242) 51242..51478 + 237 Protein_53 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / mph(A) / aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaTEM-1B / rmtB / blaCTX-M-55 - 1..161931 161931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T257673 WP_000220561.1 NZ_CP104331:46673-46954 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT257673 WP_000121743.1 NZ_CP104331:46432-46683 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References