257670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4035818..4036413 Replicon chromosome
Accession NZ_CP104330
Organism Escherichia coli strain THB42-F3

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag N0544_RS19705 Protein ID WP_000239577.1
Coordinates 4035818..4036168 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N0544_RS19710 Protein ID WP_001223208.1
Coordinates 4036162..4036413 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0544_RS19685 (4031264) 4031264..4032286 - 1023 WP_001313531.1 ABC transporter permease -
N0544_RS19690 (4032300) 4032300..4033802 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
N0544_RS19695 (4033942) 4033942..4034898 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N0544_RS19700 (4035208) 4035208..4035738 + 531 WP_000055075.1 inorganic diphosphatase -
N0544_RS19705 (4035818) 4035818..4036168 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
N0544_RS19710 (4036162) 4036162..4036413 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N0544_RS19715 (4036625) 4036625..4036966 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N0544_RS19720 (4036969) 4036969..4040748 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T257670 WP_000239577.1 NZ_CP104330:c4036168-4035818 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT257670 WP_001223208.1 NZ_CP104330:c4036413-4036162 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References