257662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2369536..2370174 Replicon chromosome
Accession NZ_CP104330
Organism Escherichia coli strain THB42-F3

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N0544_RS11480 Protein ID WP_000813794.1
Coordinates 2369998..2370174 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0544_RS11475 Protein ID WP_001270286.1
Coordinates 2369536..2369952 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0544_RS11455 (2364688) 2364688..2365629 - 942 WP_001251304.1 ABC transporter permease -
N0544_RS11460 (2365630) 2365630..2366643 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N0544_RS11465 (2366661) 2366661..2367806 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N0544_RS11470 (2368051) 2368051..2369457 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N0544_RS11475 (2369536) 2369536..2369952 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N0544_RS11480 (2369998) 2369998..2370174 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N0544_RS11485 (2370396) 2370396..2370626 + 231 WP_000494244.1 YncJ family protein -
N0544_RS11490 (2370718) 2370718..2372679 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N0544_RS11495 (2372752) 2372752..2373288 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N0544_RS11500 (2373380) 2373380..2374555 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257662 WP_000813794.1 NZ_CP104330:c2370174-2369998 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257662 WP_001270286.1 NZ_CP104330:c2369952-2369536 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References