Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 26058..26580 Replicon plasmid pHB42-F2
Accession NZ_CP104329
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N0499_RS22500 Protein ID WP_000220561.1
Coordinates 26299..26580 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N0499_RS22495 Protein ID WP_000121743.1
Coordinates 26058..26309 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS22475 (N0499_22475) 22181..22534 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
N0499_RS22480 (N0499_22480) 22671..23117 - 447 WP_001074384.1 hypothetical protein -
N0499_RS22485 (N0499_22485) 23121..23963 - 843 WP_000435064.1 replication initiation protein -
N0499_RS22490 (N0499_22490) 23984..24823 - 840 WP_024129959.1 replication initiation protein -
N0499_RS22495 (N0499_22495) 26058..26309 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N0499_RS22500 (N0499_22500) 26299..26580 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0499_RS22505 (N0499_22505) 26819..26911 - 93 Protein_31 IS6 family transposase -
N0499_RS22510 (N0499_22510) 27077..28276 - 1200 WP_000948429.1 IS91 family transposase -
N0499_RS22515 (N0499_22515) 28286..28474 - 189 WP_000957857.1 hypothetical protein -
N0499_RS22520 (N0499_22520) 28594..30024 + 1431 Protein_34 IS4-like element IS50R family transposase -
N0499_RS22525 (N0499_22525) 30053..30847 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
N0499_RS22530 (N0499_22530) 30868..31104 + 237 Protein_36 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / aph(3')-IIa / mcr-1.1 - 1..123517 123517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T257642 WP_000220561.1 NZ_CP104329:26299-26580 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT257642 WP_000121743.1 NZ_CP104329:26058-26309 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References