Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4034923..4035518 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag N0499_RS19695 Protein ID WP_000239577.1
Coordinates 4034923..4035273 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N0499_RS19700 Protein ID WP_001223208.1
Coordinates 4035267..4035518 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS19675 (4030369) 4030369..4031391 - 1023 WP_001313531.1 ABC transporter permease -
N0499_RS19680 (4031405) 4031405..4032907 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
N0499_RS19685 (4033047) 4033047..4034003 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N0499_RS19690 (4034313) 4034313..4034843 + 531 WP_000055075.1 inorganic diphosphatase -
N0499_RS19695 (4034923) 4034923..4035273 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
N0499_RS19700 (4035267) 4035267..4035518 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N0499_RS19705 (4035730) 4035730..4036071 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N0499_RS19710 (4036074) 4036074..4039853 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T257640 WP_000239577.1 NZ_CP104328:c4035273-4034923 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT257640 WP_001223208.1 NZ_CP104328:c4035518-4035267 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References