257639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3949912..3950726 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N0499_RS19260 Protein ID WP_001054376.1
Coordinates 3949912..3950169 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag N0499_RS19265 Protein ID WP_001309181.1
Coordinates 3950181..3950726 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS19235 (3945200) 3945200..3946306 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
N0499_RS19240 (3946371) 3946371..3947351 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N0499_RS19245 (3947461) 3947461..3947666 + 206 Protein_3758 HNH endonuclease -
N0499_RS19250 (3947934) 3947934..3949174 - 1241 Protein_3759 helicase YjhR -
N0499_RS19255 (3949290) 3949290..3949421 + 132 WP_001309182.1 hypothetical protein -
N0499_RS19260 (3949912) 3949912..3950169 + 258 WP_001054376.1 YjhX family toxin Toxin
N0499_RS19265 (3950181) 3950181..3950726 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
N0499_RS19270 (3950782) 3950782..3951528 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N0499_RS19275 (3951697) 3951697..3951915 + 219 Protein_3764 hypothetical protein -
N0499_RS19280 (3951953) 3951953..3952069 + 117 Protein_3765 VOC family protein -
N0499_RS19285 (3952314) 3952314..3953435 + 1122 WP_000010829.1 M42 family metallopeptidase -
N0499_RS19290 (3953432) 3953432..3953710 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N0499_RS19295 (3953722) 3953722..3955035 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3938922..3958950 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T257639 WP_001054376.1 NZ_CP104328:3949912-3950169 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT257639 WP_001309181.1 NZ_CP104328:3950181-3950726 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References