Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2369839..2370477 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N0499_RS11480 Protein ID WP_000813794.1
Coordinates 2370301..2370477 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0499_RS11475 Protein ID WP_001270286.1
Coordinates 2369839..2370255 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS11455 (2364991) 2364991..2365932 - 942 WP_001251304.1 ABC transporter permease -
N0499_RS11460 (2365933) 2365933..2366946 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N0499_RS11465 (2366964) 2366964..2368109 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N0499_RS11470 (2368354) 2368354..2369760 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N0499_RS11475 (2369839) 2369839..2370255 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N0499_RS11480 (2370301) 2370301..2370477 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N0499_RS11485 (2370699) 2370699..2370929 + 231 WP_000494244.1 YncJ family protein -
N0499_RS11490 (2371021) 2371021..2372982 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N0499_RS11495 (2373055) 2373055..2373591 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N0499_RS11500 (2373644) 2373644..2374858 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257632 WP_000813794.1 NZ_CP104328:c2370477-2370301 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257632 WP_001270286.1 NZ_CP104328:c2370255-2369839 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References