Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 845001..845655 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag N0499_RS04105 Protein ID WP_000244777.1
Coordinates 845248..845655 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N0499_RS04100 Protein ID WP_000354046.1
Coordinates 845001..845267 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS04075 (840170) 840170..840913 + 744 WP_000951964.1 SDR family oxidoreductase -
N0499_RS04080 (840970) 840970..842403 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
N0499_RS04085 (842448) 842448..842759 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N0499_RS04090 (842923) 842923..843582 + 660 WP_072647361.1 hemolysin III family protein -
N0499_RS04095 (843778) 843778..844758 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N0499_RS04100 (845001) 845001..845267 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N0499_RS04105 (845248) 845248..845655 + 408 WP_000244777.1 protein YgfX Toxin
N0499_RS04110 (845695) 845695..846216 - 522 WP_001055874.1 flavodoxin FldB -
N0499_RS04115 (846328) 846328..847224 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N0499_RS04120 (847249) 847249..847959 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N0499_RS04125 (847965) 847965..849698 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T257620 WP_000244777.1 NZ_CP104328:845248-845655 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT257620 WP_000354046.1 NZ_CP104328:845001-845267 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References