Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 49118..49640 Replicon plasmid pHB42-F1
Accession NZ_CP104327
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N0470_RS22830 Protein ID WP_000220561.1
Coordinates 49359..49640 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N0470_RS22825 Protein ID WP_000121743.1
Coordinates 49118..49369 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS22805 (45241) 45241..45594 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
N0470_RS22810 (45731) 45731..46177 - 447 WP_001074384.1 hypothetical protein -
N0470_RS22815 (46181) 46181..47023 - 843 WP_000435064.1 replication initiation protein -
N0470_RS22820 (47044) 47044..47883 - 840 WP_024129959.1 replication initiation protein -
N0470_RS22825 (49118) 49118..49369 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N0470_RS22830 (49359) 49359..49640 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0470_RS22835 (49879) 49879..49971 - 93 Protein_51 IS6 family transposase -
N0470_RS22840 (50137) 50137..51336 - 1200 WP_000948429.1 IS91 family transposase -
N0470_RS22845 (51346) 51346..51534 - 189 WP_000957857.1 hypothetical protein -
N0470_RS22850 (51654) 51654..53084 + 1431 Protein_54 IS4-like element IS50R family transposase -
N0470_RS22855 (53113) 53113..53907 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
N0470_RS22860 (53928) 53928..54164 + 237 Protein_56 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA12 / aadA2 / qacE / mph(A) / blaTEM-1B / aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / rmtB / blaCTX-M-55 - 1..162761 162761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T257612 WP_000220561.1 NZ_CP104327:49359-49640 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT257612 WP_000121743.1 NZ_CP104327:49118-49369 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References