257609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4078045..4078640 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag N0470_RS19920 Protein ID WP_000239577.1
Coordinates 4078045..4078395 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N0470_RS19925 Protein ID WP_001223208.1
Coordinates 4078389..4078640 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS19900 (4073491) 4073491..4074513 - 1023 WP_001313531.1 ABC transporter permease -
N0470_RS19905 (4074527) 4074527..4076029 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
N0470_RS19910 (4076169) 4076169..4077125 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N0470_RS19915 (4077435) 4077435..4077965 + 531 WP_000055075.1 inorganic diphosphatase -
N0470_RS19920 (4078045) 4078045..4078395 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
N0470_RS19925 (4078389) 4078389..4078640 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N0470_RS19930 (4078852) 4078852..4079193 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N0470_RS19935 (4079196) 4079196..4082975 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T257609 WP_000239577.1 NZ_CP104326:c4078395-4078045 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT257609 WP_001223208.1 NZ_CP104326:c4078640-4078389 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References