257608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3993034..3993848 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N0470_RS19485 Protein ID WP_001054376.1
Coordinates 3993034..3993291 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag N0470_RS19490 Protein ID WP_001309181.1
Coordinates 3993303..3993848 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS19460 (3988322) 3988322..3989428 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
N0470_RS19465 (3989493) 3989493..3990473 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N0470_RS19470 (3990583) 3990583..3990788 + 206 Protein_3803 HNH endonuclease -
N0470_RS19475 (3991056) 3991056..3992296 - 1241 Protein_3804 helicase YjhR -
N0470_RS19480 (3992412) 3992412..3992543 + 132 WP_001309182.1 hypothetical protein -
N0470_RS19485 (3993034) 3993034..3993291 + 258 WP_001054376.1 YjhX family toxin Toxin
N0470_RS19490 (3993303) 3993303..3993848 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
N0470_RS19495 (3993904) 3993904..3994650 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N0470_RS19500 (3994819) 3994819..3995037 + 219 Protein_3809 hypothetical protein -
N0470_RS19505 (3995075) 3995075..3995191 + 117 Protein_3810 VOC family protein -
N0470_RS19510 (3995436) 3995436..3996557 + 1122 WP_000010829.1 M42 family metallopeptidase -
N0470_RS19515 (3996554) 3996554..3996832 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N0470_RS19520 (3996844) 3996844..3998157 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3982044..4002072 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T257608 WP_001054376.1 NZ_CP104326:3993034-3993291 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT257608 WP_001309181.1 NZ_CP104326:3993303-3993848 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References