Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3404617..3405235 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N0470_RS16605 Protein ID WP_001291435.1
Coordinates 3405017..3405235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N0470_RS16600 Protein ID WP_000344800.1
Coordinates 3404617..3404991 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS16590 (3399706) 3399706..3400899 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N0470_RS16595 (3400922) 3400922..3404071 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N0470_RS16600 (3404617) 3404617..3404991 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N0470_RS16605 (3405017) 3405017..3405235 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N0470_RS16610 (3405407) 3405407..3405958 + 552 WP_000102564.1 maltose O-acetyltransferase -
N0470_RS16615 (3406074) 3406074..3406544 + 471 WP_001716237.1 YlaC family protein -
N0470_RS16620 (3406708) 3406708..3408258 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N0470_RS16625 (3408300) 3408300..3408653 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N0470_RS16635 (3409032) 3409032..3409343 + 312 WP_000409911.1 MGMT family protein -
N0470_RS16640 (3409374) 3409374..3409946 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257602 WP_001291435.1 NZ_CP104326:3405017-3405235 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257602 WP_000344800.1 NZ_CP104326:3404617-3404991 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References