Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2375646..2376284 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N0470_RS11525 Protein ID WP_000813794.1
Coordinates 2376108..2376284 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0470_RS11520 Protein ID WP_001270286.1
Coordinates 2375646..2376062 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS11500 (2370798) 2370798..2371739 - 942 WP_001251304.1 ABC transporter permease -
N0470_RS11505 (2371740) 2371740..2372753 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N0470_RS11510 (2372771) 2372771..2373916 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N0470_RS11515 (2374161) 2374161..2375567 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N0470_RS11520 (2375646) 2375646..2376062 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N0470_RS11525 (2376108) 2376108..2376284 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N0470_RS11530 (2376506) 2376506..2376736 + 231 WP_000494244.1 YncJ family protein -
N0470_RS11535 (2376828) 2376828..2378789 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N0470_RS11540 (2378862) 2378862..2379398 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N0470_RS11545 (2379451) 2379451..2380665 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257601 WP_000813794.1 NZ_CP104326:c2376284-2376108 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257601 WP_001270286.1 NZ_CP104326:c2376062-2375646 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References