Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6165881..6166445 Replicon chromosome
Accession NZ_CP104317
Organism Streptomyces angustmyceticus strain CQUSa03

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW605_RS26890 Protein ID WP_260638778.1
Coordinates 6165881..6166228 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NW605_RS26895 Protein ID WP_260638779.1
Coordinates 6166215..6166445 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW605_RS26875 6161539..6162561 + 1023 WP_086717413.1 hypothetical protein -
NW605_RS26880 6162579..6164324 - 1746 WP_260638776.1 TIGR03767 family metallophosphoesterase -
NW605_RS26885 6164750..6165781 + 1032 WP_260638777.1 aspartate-semialdehyde dehydrogenase -
NW605_RS26890 6165881..6166228 - 348 WP_260638778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW605_RS26895 6166215..6166445 - 231 WP_260638779.1 ribbon-helix-helix domain-containing protein Antitoxin
NW605_RS26900 6166571..6169165 + 2595 WP_260638780.1 aminopeptidase N -
NW605_RS26905 6169363..6170508 - 1146 WP_260638781.1 allantoicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12842.88 Da        Isoelectric Point: 10.7646

>T257582 WP_260638778.1 NZ_CP104317:c6166228-6165881 [Streptomyces angustmyceticus]
MRRGDIYMVDLEPTRGSEANKIRPALIVSHNGANQSVEAHRRGVVTVVPLTSNTSRVLSFQVLLEAEECRLPKDSKAQCE
QLRAVAPERVLHKVGVVPRRRMAEVDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8418.18 Da        Isoelectric Point: 3.8962

>AT257582 WP_260638779.1 NZ_CP104317:c6166445-6166215 [Streptomyces angustmyceticus]
MKISVSLPQEDVAFVDEYAARTAGESRSAVIHAAIELLRAAQLEAEYTEAFAEWDTSEDAALWDRTSRDGLADEAW

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References