Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3372..3952 Replicon plasmid pKP81321
Accession NZ_CP104313
Organism Klebsiella pneumoniae strain KP8132

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag N2X67_RS26615 Protein ID WP_071177730.1
Coordinates 3372..3686 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag N2X67_RS26620 Protein ID WP_000093040.1
Coordinates 3674..3952 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X67_RS26595 (N2X67_26595) 1280..2011 + 732 WP_071177728.1 MobC family replication-relaxation protein -
N2X67_RS26600 (N2X67_26600) 2018..2548 + 531 WP_071177729.1 hypothetical protein -
N2X67_RS26605 (N2X67_26605) 2575..2754 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
N2X67_RS26610 (N2X67_26610) 2780..3208 - 429 WP_001140599.1 hypothetical protein -
N2X67_RS26615 (N2X67_26615) 3372..3686 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2X67_RS26620 (N2X67_26620) 3674..3952 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
N2X67_RS26625 (N2X67_26625) 4127..4492 - 366 WP_072354022.1 TonB family protein -
N2X67_RS26630 (N2X67_26630) 4489..4860 - 372 WP_001237044.1 cell envelope integrity protein TolA -
N2X67_RS26635 (N2X67_26635) 5134..5379 - 246 WP_032440458.1 hypothetical protein -
N2X67_RS26640 (N2X67_26640) 6024..7511 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
N2X67_RS26645 (N2X67_26645) 7616..8359 + 744 Protein_11 cloacin -
N2X67_RS26650 (N2X67_26650) 8455..8532 + 78 WP_260714748.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..12047 12047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T257571 WP_071177730.1 NZ_CP104313:c3686-3372 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT257571 WP_000093040.1 NZ_CP104313:c3952-3674 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References