Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4842853..4843369 Replicon chromosome
Accession NZ_CP104312
Organism Klebsiella pneumoniae strain KP8132

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N2X67_RS23895 Protein ID WP_002886902.1
Coordinates 4842853..4843137 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N2X67_RS23900 Protein ID WP_002886901.1
Coordinates 4843127..4843369 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X67_RS23870 (N2X67_23870) 4838337..4838600 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
N2X67_RS23875 (N2X67_23875) 4838730..4838903 + 174 WP_002886906.1 hypothetical protein -
N2X67_RS23880 (N2X67_23880) 4838906..4839649 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N2X67_RS23885 (N2X67_23885) 4840006..4842144 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
N2X67_RS23890 (N2X67_23890) 4842385..4842849 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N2X67_RS23895 (N2X67_23895) 4842853..4843137 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2X67_RS23900 (N2X67_23900) 4843127..4843369 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N2X67_RS23905 (N2X67_23905) 4843447..4845357 - 1911 WP_004152270.1 PRD domain-containing protein -
N2X67_RS23910 (N2X67_23910) 4845380..4846534 - 1155 WP_002886900.1 lactonase family protein -
N2X67_RS23915 (N2X67_23915) 4846600..4847340 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T257568 WP_002886902.1 NZ_CP104312:c4843137-4842853 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT257568 WP_002886901.1 NZ_CP104312:c4843369-4843127 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References