Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2709265..2710853 Replicon chromosome
Accession NZ_CP104312
Organism Klebsiella pneumoniae strain KP8132

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag N2X67_RS13380 Protein ID WP_004199851.1
Coordinates 2709265..2710587 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N2X67_RS13385 Protein ID WP_002904790.1
Coordinates 2710587..2710853 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X67_RS13365 (N2X67_13365) 2704330..2706831 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
N2X67_RS13370 (N2X67_13370) 2706819..2707823 + 1005 WP_004199852.1 fimbrial protein -
N2X67_RS13375 (N2X67_13375) 2707956..2709248 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N2X67_RS13380 (N2X67_13380) 2709265..2710587 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
N2X67_RS13385 (N2X67_13385) 2710587..2710853 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N2X67_RS13390 (N2X67_13390) 2711119..2711445 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N2X67_RS13395 (N2X67_13395) 2711442..2711942 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N2X67_RS13400 (N2X67_13400) 2711920..2713299 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
N2X67_RS13405 (N2X67_13405) 2713645..2714799 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N2X67_RS13410 (N2X67_13410) 2714780..2715703 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T257564 WP_004199851.1 NZ_CP104312:c2710587-2709265 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT257564 WP_002904790.1 NZ_CP104312:c2710853-2710587 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References