Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4846632..4847227 Replicon chromosome
Accession NZ_CP104309
Organism Escherichia coli O157:H7 strain 380-94

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NUE46_RS24295 Protein ID WP_000239579.1
Coordinates 4846632..4846982 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag NUE46_RS24300 Protein ID WP_001223210.1
Coordinates 4846976..4847227 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE46_RS24275 (4842078) 4842078..4843100 - 1023 WP_001301928.1 ABC transporter permease -
NUE46_RS24280 (4843114) 4843114..4844616 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
NUE46_RS24285 (4844756) 4844756..4845712 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NUE46_RS24290 (4846022) 4846022..4846552 + 531 WP_000055075.1 inorganic diphosphatase -
NUE46_RS24295 (4846632) 4846632..4846982 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NUE46_RS24300 (4846976) 4846976..4847227 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NUE46_RS24305 (4847439) 4847439..4847780 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NUE46_RS24310 (4847783) 4847783..4851562 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T257552 WP_000239579.1 NZ_CP104309:c4846982-4846632 [Escherichia coli O157:H7]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT257552 WP_001223210.1 NZ_CP104309:c4847227-4846976 [Escherichia coli O157:H7]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References