25755

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2796425..2797044 Replicon chromosome
Accession NC_016612
Organism Klebsiella oxytoca KCTC 1686

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag KOX_RS13000 Protein ID WP_004099646.1
Coordinates 2796425..2796643 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag KOX_RS13005 Protein ID WP_004129911.1
Coordinates 2796670..2797044 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOX_RS12970 2792470..2792733 + 264 WP_004848323.1 type B 50S ribosomal protein L31 -
KOX_RS12975 2792733..2792873 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KOX_RS12980 2792870..2793568 - 699 WP_014228203.1 GNAT family N-acetyltransferase -
KOX_RS12985 2793670..2795124 + 1455 WP_014228204.1 PLP-dependent aminotransferase family protein -
KOX_RS12990 2795099..2795569 - 471 WP_014228205.1 YlaC family protein -
KOX_RS12995 2795696..2796262 - 567 Protein_2558 maltose O-acetyltransferase -
KOX_RS13000 2796425..2796643 - 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
KOX_RS13005 2796670..2797044 - 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
KOX_RS13010 2797525..2800671 - 3147 WP_014228207.1 multidrug efflux RND transporter permease subunit -
KOX_RS13015 2800694..2801887 - 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T25755 WP_004099646.1 NC_016612:c2796643-2796425 [Klebsiella michiganensis KCTC 1686]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T25755 NC_016612:c2796643-2796425 [Klebsiella michiganensis KCTC 1686]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT25755 WP_004129911.1 NC_016612:c2797044-2796670 [Klebsiella michiganensis KCTC 1686]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT25755 NC_016612:c2797044-2796670 [Klebsiella michiganensis KCTC 1686]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References