Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3612325..3613030 Replicon chromosome
Accession NZ_CP104309
Organism Escherichia coli O157:H7 strain 380-94

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag NUE46_RS18545 Protein ID WP_000539519.1
Coordinates 3612325..3612711 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUE46_RS18550 Protein ID WP_001280945.1
Coordinates 3612701..3613030 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE46_RS18525 (3608329) 3608329..3608955 + 627 WP_001295292.1 glutathione S-transferase GstB -
NUE46_RS18530 (3608952) 3608952..3610067 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
NUE46_RS18535 (3610178) 3610178..3610561 - 384 WP_000497137.1 biofilm formation regulator BssR -
NUE46_RS18540 (3610774) 3610774..3612099 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NUE46_RS18545 (3612325) 3612325..3612711 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUE46_RS18550 (3612701) 3612701..3613030 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NUE46_RS18555 (3613100) 3613100..3614428 - 1329 WP_000086905.1 GGDEF domain-containing protein -
NUE46_RS18560 (3614436) 3614436..3616784 - 2349 WP_000950320.1 EAL domain-containing protein -
NUE46_RS18565 (3616962) 3616962..3617873 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T257546 WP_000539519.1 NZ_CP104309:3612325-3612711 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT257546 WP_001280945.1 NZ_CP104309:3612701-3613030 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References