Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2676520..2677158 Replicon chromosome
Accession NZ_CP104309
Organism Escherichia coli O157:H7 strain 380-94

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NUE46_RS13485 Protein ID WP_000813794.1
Coordinates 2676520..2676696 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NUE46_RS13490 Protein ID WP_001270286.1
Coordinates 2676742..2677158 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE46_RS13465 (2672142) 2672142..2673314 - 1173 WP_001236316.1 BenE family transporter YdcO -
NUE46_RS13470 (2673406) 2673406..2673942 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
NUE46_RS13475 (2674015) 2674015..2675976 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NUE46_RS13480 (2676068) 2676068..2676298 - 231 WP_000494244.1 YncJ family protein -
NUE46_RS13485 (2676520) 2676520..2676696 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NUE46_RS13490 (2676742) 2676742..2677158 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NUE46_RS13495 (2677237) 2677237..2678643 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
NUE46_RS13500 (2678888) 2678888..2680033 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
NUE46_RS13505 (2680051) 2680051..2681064 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
NUE46_RS13510 (2681065) 2681065..2682006 + 942 WP_001251320.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257543 WP_000813794.1 NZ_CP104309:2676520-2676696 [Escherichia coli O157:H7]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257543 WP_001270286.1 NZ_CP104309:2676742-2677158 [Escherichia coli O157:H7]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References