25754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 2558630..2559449 Replicon chromosome
Accession NC_016612
Organism Klebsiella oxytoca KCTC 1686

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag KOX_RS11910 Protein ID WP_004110819.1
Coordinates 2558630..2558887 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A0H3H6E6
Locus tag KOX_RS11915 Protein ID WP_014228055.1
Coordinates 2558898..2559449 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOX_RS11895 2554306..2555082 - 777 WP_004847986.1 Uxu operon transcriptional regulator -
KOX_RS11900 2555221..2556696 - 1476 WP_014228053.1 fructuronate reductase -
KOX_RS11905 2556770..2557954 - 1185 WP_014228054.1 mannonate dehydratase -
KOX_RS11910 2558630..2558887 + 258 WP_004110819.1 YjhX family toxin Toxin
KOX_RS11915 2558898..2559449 + 552 WP_014228055.1 N-acetyltransferase Antitoxin
KOX_RS11920 2559467..2561095 + 1629 WP_038423349.1 SAM-dependent methyltransferase -
KOX_RS11925 2561310..2562197 - 888 WP_014228057.1 DMT family transporter -
KOX_RS11930 2562317..2563225 + 909 WP_014228058.1 transcriptional regulator GcvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T25754 WP_004110819.1 NC_016612:2558630-2558887 [Klebsiella michiganensis KCTC 1686]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T25754 NC_016612:2558630-2558887 [Klebsiella michiganensis KCTC 1686]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20048.90 Da        Isoelectric Point: 6.3992

>AT25754 WP_014228055.1 NC_016612:2558898-2559449 [Klebsiella michiganensis KCTC 1686]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRYGFEPCAGDKGYPAPYPIPAAHKGCWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT25754 NC_016612:2558898-2559449 [Klebsiella michiganensis KCTC 1686]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGATGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGTACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGGCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H6E6

References