Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 421476..422070 Replicon chromosome
Accession NZ_CP104307
Organism Flavobacterium sp. TR2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N4T20_RS02055 Protein ID WP_260671472.1
Coordinates 421828..422070 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4T20_RS02050 Protein ID WP_260671471.1
Coordinates 421476..421826 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T20_RS02025 (N4T20_02025) 417427..417912 + 486 WP_073418297.1 5-(carboxyamino)imidazole ribonucleotide mutase -
N4T20_RS02030 (N4T20_02030) 418073..418300 + 228 WP_260671467.1 hypothetical protein -
N4T20_RS02035 (N4T20_02035) 418300..418587 + 288 WP_260671468.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T20_RS02040 (N4T20_02040) 418624..420651 + 2028 WP_260671469.1 M3 family metallopeptidase -
N4T20_RS02045 (N4T20_02045) 420783..421442 + 660 WP_260671470.1 ElyC/SanA/YdcF family protein -
N4T20_RS02050 (N4T20_02050) 421476..421826 - 351 WP_260671471.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N4T20_RS02055 (N4T20_02055) 421828..422070 - 243 WP_260671472.1 type II toxin-antitoxin system HicA family toxin Toxin
N4T20_RS02060 (N4T20_02060) 422237..423499 - 1263 WP_260671473.1 sodium:proton antiporter -
N4T20_RS02065 (N4T20_02065) 424077..424889 - 813 WP_260671474.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9458.05 Da        Isoelectric Point: 9.9791

>T257527 WP_260671472.1 NZ_CP104307:c422070-421828 [Flavobacterium sp. TR2]
MSKIDKLIEKLKSKPKDFSWDEMVKVLKYFGYEQISQGKTGGSRRKFVNENKQIISLHEPHPQKVLKSYQLDIIIEHLEL

Download         Length: 243 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13201.99 Da        Isoelectric Point: 4.7746

>AT257527 WP_260671471.1 NZ_CP104307:c421826-421476 [Flavobacterium sp. TR2]
MKNYLEYNGYIGTLEFSADDKIFFGKIQGINDLVTFEGSSVTELEESFKEAVDDYLETCKLLNKAPDKTYKGSFNVRVSQ
ELHQKISLLATKKGLNLNEIVKEALSYVVKHEEILN

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References