Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2371963..2372642 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Z93_RS11460 Protein ID WP_090584775.1
Coordinates 2371963..2372367 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Z93_RS11465 Protein ID WP_090584777.1
Coordinates 2372364..2372642 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS11440 (L2Z93_002282) 2367308..2368864 + 1557 WP_090584769.1 alpha/beta fold hydrolase -
L2Z93_RS11445 (L2Z93_002283) 2368935..2370200 + 1266 Protein_2243 glycosyltransferase family 87 protein -
L2Z93_RS11450 (L2Z93_002284) 2370506..2371327 - 822 Protein_2244 hypothetical protein -
L2Z93_RS11455 (L2Z93_002285) 2371515..2371940 + 426 WP_090584773.1 peptide-methionine (R)-S-oxide reductase MsrB -
L2Z93_RS11460 (L2Z93_002286) 2371963..2372367 - 405 WP_090584775.1 type II toxin-antitoxin system VapC family toxin Toxin
L2Z93_RS11465 (L2Z93_002287) 2372364..2372642 - 279 WP_090584777.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L2Z93_RS11470 (L2Z93_002288) 2372680..2373432 - 753 WP_090584779.1 class I SAM-dependent methyltransferase -
L2Z93_RS11475 (L2Z93_002289) 2373441..2374133 - 693 WP_090584980.1 chlorite dismutase family protein -
L2Z93_RS11480 (L2Z93_002290) 2374158..2375501 - 1344 WP_090584982.1 protoporphyrinogen oxidase -
L2Z93_RS11485 (L2Z93_002291) 2375555..2376616 - 1062 WP_090584781.1 uroporphyrinogen decarboxylase -
L2Z93_RS11490 (L2Z93_002292) 2376724..2377305 + 582 WP_090584783.1 DUF3000 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14386.54 Da        Isoelectric Point: 4.5502

>T257520 WP_090584775.1 NZ_CP104302:c2372367-2371963 [Mycolicibacterium brumae]
MIYLDTSALVKLLVTEDETPALRRWLSEQTSGGVFAATSTLGRIELMRAAARYSEPGLADRARFLLDGMDLLPLTESVLT
LAETIGPPSLRSLDAIHLAAAAHVRDELTAFVTYDRRLLDGCCDVGLAVVSPGA

Download         Length: 405 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9927.34 Da        Isoelectric Point: 7.0174

>AT257520 WP_090584777.1 NZ_CP104302:c2372642-2372364 [Mycolicibacterium brumae]
MESIGVRELRQHASRYLARVEAGEELAVTNNGRVVARLVPVGAAERSRAALIESGALIPARRPENLLVVTAAPQREGKPS
LSAVLAEMRDEE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References