Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 972917..973584 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Z93_RS04940 Protein ID WP_090586806.1
Coordinates 972917..973348 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Z93_RS04945 Protein ID WP_090586804.1
Coordinates 973345..973584 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS04920 (L2Z93_000981) 968485..969504 + 1020 WP_090586976.1 alcohol dehydrogenase AdhP -
L2Z93_RS04925 (L2Z93_000982) 969563..970222 - 660 WP_090586811.1 response regulator transcription factor -
L2Z93_RS04930 (L2Z93_000983) 970219..971610 - 1392 WP_162561874.1 histidine kinase -
L2Z93_RS04935 (L2Z93_000984) 971607..972803 - 1197 WP_090586809.1 iron-containing alcohol dehydrogenase -
L2Z93_RS04940 (L2Z93_000985) 972917..973348 - 432 WP_090586806.1 PIN domain-containing protein Toxin
L2Z93_RS04945 (L2Z93_000986) 973345..973584 - 240 WP_090586804.1 antitoxin Antitoxin
L2Z93_RS04955 (L2Z93_000988) 974189..975718 + 1530 WP_090586801.1 HNH endonuclease signature motif containing protein -
L2Z93_RS04960 (L2Z93_000989) 975864..977516 + 1653 WP_090586799.1 arginine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(4-138)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15716.81 Da        Isoelectric Point: 7.1714

>T257515 WP_090586806.1 NZ_CP104302:c973348-972917 [Mycolicibacterium brumae]
VKRALLDVNVLIALFDSDHVDHGRVRAWLAAEIAHGWASCAITQNGFIRIISQPRYPSPVAPAQAITRLATATSTEHHKY
WSCSISLLDADLIDHSRLHGHRQVTDAYLLALATSNDARFVTLDQSIGLNTVRNATPDNLTVI

Download         Length: 432 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8694.71 Da        Isoelectric Point: 6.7268

>AT257515 WP_090586804.1 NZ_CP104302:c973584-973345 [Mycolicibacterium brumae]
MRTTLSLDDDVLLAVKERARREKRTAGEVLSDLARHALQQHSAESGRATGDLHGFEPFGRRGPAVSNALVDKLRDEEAV

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References