Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 837827..838389 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L2Z93_RS04345 Protein ID WP_090589299.1
Coordinates 837827..838156 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L2Z93_RS04350 Protein ID WP_090589300.1
Coordinates 838153..838389 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS04320 (L2Z93_000861) 832939..833358 - 420 WP_090589294.1 cupin domain-containing protein -
L2Z93_RS04325 (L2Z93_000862) 833876..834787 - 912 WP_128111806.1 hypothetical protein -
L2Z93_RS04330 (L2Z93_000863) 835096..835761 - 666 WP_090589296.1 hypothetical protein -
L2Z93_RS04335 (L2Z93_000864) 835853..836830 - 978 WP_128111807.1 hypothetical protein -
L2Z93_RS04340 (L2Z93_000865) 836932..837825 + 894 WP_090589298.1 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase -
L2Z93_RS04345 (L2Z93_000866) 837827..838156 - 330 WP_090589299.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L2Z93_RS04350 (L2Z93_000867) 838153..838389 - 237 WP_090589300.1 DUF2191 domain-containing protein Antitoxin
L2Z93_RS04355 (L2Z93_000868) 838476..838859 + 384 WP_090589301.1 hypothetical protein -
L2Z93_RS04360 (L2Z93_000869) 838949..840181 - 1233 WP_090589302.1 hypothetical protein -
L2Z93_RS04365 (L2Z93_000870) 840432..843011 + 2580 WP_090589303.1 bifunctional FO biosynthesis protein CofGH -
L2Z93_RS04370 (L2Z93_000871) 843040..843378 - 339 WP_128111808.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11668.60 Da        Isoelectric Point: 8.1265

>T257514 WP_090589299.1 NZ_CP104302:c838156-837827 [Mycolicibacterium brumae]
MSGLPTRGEVWWCELPDIGRRPVVVISRDVAIPRTRRPLVAPCTTTIRGLPSEVQLEPGVDPVPRPSAVNLDSIESVAIG
SLVERLGRLADDRMRAICSALKVATGCGA

Download         Length: 330 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8201.95 Da        Isoelectric Point: 4.3719

>AT257514 WP_090589300.1 NZ_CP104302:c838389-838153 [Mycolicibacterium brumae]
MSRIRVSTTVDADLLHAARQTRSGGTDASLLDAALSALLTAHRAAQIDAAYVAYDSQPLSDPDEWGDLASWRDAAGSS

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References