Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 306961..307522 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L2Z93_RS01540 Protein ID WP_090588994.1
Coordinates 307178..307522 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L2Z93_RS01535 Protein ID WP_090588993.1
Coordinates 306961..307191 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS01510 (L2Z93_000302) 302398..302769 - 372 WP_234786129.1 hypothetical protein -
L2Z93_RS01515 (L2Z93_000303) 302883..303506 + 624 WP_090588991.1 class I SAM-dependent methyltransferase -
L2Z93_RS01520 (L2Z93_000304) 303885..305462 - 1578 WP_090589005.1 adenylate/guanylate cyclase domain-containing protein -
L2Z93_RS01525 (L2Z93_000305) 305601..306815 + 1215 WP_090588992.1 DNA polymerase III subunit delta' -
L2Z93_RS01535 (L2Z93_000307) 306961..307191 + 231 WP_090588993.1 antitoxin Antitoxin
L2Z93_RS01540 (L2Z93_000308) 307178..307522 + 345 WP_090588994.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L2Z93_RS01545 (L2Z93_000309) 307586..307816 - 231 WP_090588995.1 hypothetical protein -
L2Z93_RS01550 (L2Z93_000310) 307966..308717 + 752 Protein_297 MFS transporter -
L2Z93_RS01555 (L2Z93_000311) 309211..312168 + 2958 WP_090588996.1 PE-PPE domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306961..319795 12834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-114)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 12332.04 Da        Isoelectric Point: 10.0733

>T257512 WP_090588994.1 NZ_CP104302:307178-307522 [Mycolicibacterium brumae]
MLRGEVWQVDLDPVRGSEADKRRPAVIVSNDRANATAARLGRGVVTVVPVTSNTDTVYPFQVRLSAQSGLPVESKAQAEQ
VRSVSVHRLVRRLGHVSAAEEAALDAALKLHLEL

Download         Length: 345 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8435.19 Da        Isoelectric Point: 4.0868

>AT257512 WP_090588993.1 NZ_CP104302:306961-307191 [Mycolicibacterium brumae]
MKLSVSLSDDDVAVLDAYVKKSQLPSRSAGLQRAVQMLRHPNLEDDYEQAWSEWAGDDASEDWDRAVGDGVTDAPR

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References