Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 207257..207919 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Z93_RS01035 Protein ID WP_090592130.1
Coordinates 207524..207919 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Z93_RS01030 Protein ID WP_090592210.1
Coordinates 207257..207520 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS01005 (L2Z93_000201) 202383..203411 + 1029 WP_162561876.1 ATP-dependent DNA ligase -
L2Z93_RS01010 (L2Z93_000202) 203436..203945 + 510 WP_193438885.1 hypothetical protein -
L2Z93_RS01015 (L2Z93_000203) 204068..205678 + 1611 WP_260575493.1 HNH endonuclease signature motif containing protein -
L2Z93_RS01020 (L2Z93_000204) 205862..206878 - 1017 WP_234812035.1 S1C family serine protease -
L2Z93_RS01030 (L2Z93_000206) 207257..207520 + 264 WP_090592210.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L2Z93_RS01035 (L2Z93_000207) 207524..207919 + 396 WP_090592130.1 type II toxin-antitoxin system VapC family toxin Toxin
L2Z93_RS01040 (L2Z93_000208) 208003..208674 - 672 WP_128111781.1 hypothetical protein -
L2Z93_RS01045 (L2Z93_000209) 208760..209137 + 378 WP_090592138.1 hypothetical protein -
L2Z93_RS01055 (L2Z93_000211) 209333..210625 + 1293 WP_090592142.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
L2Z93_RS01060 (L2Z93_000212) 210657..212765 + 2109 WP_090592146.1 DNA polymerase III subunits gamma/tau -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13793.84 Da        Isoelectric Point: 4.4227

>T257511 WP_090592130.1 NZ_CP104302:207524-207919 [Mycolicibacterium brumae]
VAYYVDISALVKLVVAEPETPALRDWIAGESAALVSSDVTRTELLRAVRRVAPERLVEARAVLDSIILSTVSTATFEAAA
LLDPTVLRSLDAVHIAAALELGDDLAGMVTYDDRMAAAARAHGIAVLAPSQ

Download         Length: 396 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9207.72 Da        Isoelectric Point: 11.9061

>AT257511 WP_090592210.1 NZ_CP104302:207257-207520 [Mycolicibacterium brumae]
MTEVGIRALKQNASAVVADAAAGSVVIITDRGRPVAQLSPLPATPLQRLLAAGRARPPRRDIRKLPAPTPGPSLSAELSK
MRDAERY

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References