Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 112919..113592 Replicon chromosome
Accession NZ_CP104302
Organism Mycolicibacterium brumae strain ATCC 51384

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Z93_RS00510 Protein ID WP_090587223.1
Coordinates 112919..113344 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Z93_RS00515 Protein ID WP_090587220.1
Coordinates 113341..113592 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z93_RS00495 (L2Z93_000099) 108848..110701 - 1854 WP_090587231.1 galactan 5-O-arabinofuranosyltransferase -
L2Z93_RS00500 (L2Z93_000100) 110703..111482 - 780 WP_090587229.1 decaprenylphospho-beta-D-erythro-pentofuranosid- 2-ulose 2-reductase -
L2Z93_RS00505 (L2Z93_000101) 111512..112891 - 1380 WP_090587225.1 FAD-binding oxidoreductase -
L2Z93_RS00510 (L2Z93_000102) 112919..113344 - 426 WP_090587223.1 type II toxin-antitoxin system VapC family toxin Toxin
L2Z93_RS00515 (L2Z93_000103) 113341..113592 - 252 WP_090587220.1 hypothetical protein Antitoxin
L2Z93_RS00520 (L2Z93_000104) 113639..114055 - 417 WP_090587218.1 GtrA family protein -
L2Z93_RS00525 (L2Z93_000105) 114096..114776 + 681 WP_202971890.1 metal-dependent phosphohydrolase -
L2Z93_RS00530 (L2Z93_000106) 114867..115304 + 438 WP_234786044.1 pyridoxamine 5'-phosphate oxidase family protein -
L2Z93_RS00535 (L2Z93_000107) 115343..116539 - 1197 WP_090587209.1 helix-turn-helix domain-containing protein -
L2Z93_RS00540 (L2Z93_000108) 116739..117173 + 435 WP_090587206.1 hypothetical protein -
L2Z93_RS00545 (L2Z93_000109) 117307..118503 - 1197 WP_090587204.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14916.05 Da        Isoelectric Point: 6.4778

>T257510 WP_090587223.1 NZ_CP104302:c113344-112919 [Mycolicibacterium brumae]
MNIVDVNVLLYAVNRQSAQHSAAHSWLSGQLRGPGTVGLSWTALLGFVRIATNPSILPRPLRPAEAFDIIDAWLASPAAV
VVEPTSRHLAILRGLLTEFGTAGNLTSDAHLAALAVEYGGVVVTFDRDFARFGVDTVTPAG

Download         Length: 426 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8884.12 Da        Isoelectric Point: 5.0336

>AT257510 WP_090587220.1 NZ_CP104302:c113592-113341 [Mycolicibacterium brumae]
MRTTVTLDSDVEVRLQALMRDRGLSFKEAINTALRAGLNAGGPVDVAFPVYDMGTPTVDLTHAGRLAAALEDEEIARKLA
SGR

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References