Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 3924328..3926023 | Replicon | chromosome |
| Accession | NZ_CP104301 | ||
| Organism | Pseudomonas aeruginosa strain PLL01 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | N4Q74_RS18250 | Protein ID | WP_003112901.1 |
| Coordinates | 3925154..3926023 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | N4Q74_RS18245 | Protein ID | WP_003112902.1 |
| Coordinates | 3924328..3925161 (-) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N4Q74_RS18225 | 3919559..3921043 | - | 1485 | WP_003112906.1 | aldehyde dehydrogenase | - |
| N4Q74_RS18230 | 3921055..3921858 | - | 804 | WP_003112905.1 | aspartate dehydrogenase | - |
| N4Q74_RS18235 | 3921869..3923551 | - | 1683 | WP_003112904.1 | thiamine pyrophosphate-binding protein | - |
| N4Q74_RS18240 | 3923544..3924341 | - | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| N4Q74_RS18245 | 3924328..3925161 | - | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| N4Q74_RS18250 | 3925154..3926023 | - | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| N4Q74_RS18255 | 3926032..3926562 | - | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| N4Q74_RS18260 | 3926576..3927337 | - | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| N4Q74_RS18265 | 3927343..3928119 | - | 777 | WP_003112898.1 | ABC transporter permease | - |
| N4Q74_RS18270 | 3928116..3929123 | - | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| N4Q74_RS18275 | 3929164..3930015 | - | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T257508 WP_003112901.1 NZ_CP104301:c3926023-3925154 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT257508 WP_003112902.1 NZ_CP104301:c3925161-3924328 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|