Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2048002..2049223 Replicon chromosome
Accession NZ_CP104301
Organism Pseudomonas aeruginosa strain PLL01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4Q74_RS09730 Protein ID WP_003114949.1
Coordinates 2048002..2048580 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N4Q74_RS09735 Protein ID WP_003088112.1
Coordinates 2048669..2049223 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4Q74_RS09715 2043279..2044556 + 1278 WP_003102743.1 TolC family protein -
N4Q74_RS09720 2044546..2046717 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
N4Q74_RS09725 2046707..2047894 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
N4Q74_RS09730 2048002..2048580 - 579 WP_003114949.1 HD domain-containing protein Toxin
N4Q74_RS09735 2048669..2049223 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
N4Q74_RS09740 2049381..2051576 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
N4Q74_RS09745 2051581..2052042 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
N4Q74_RS09750 2052373..2052696 + 324 WP_003102734.1 multidrug efflux SMR transporter -
N4Q74_RS09755 2052709..2053107 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
N4Q74_RS09760 2053104..2053655 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T257506 WP_003114949.1 NZ_CP104301:c2048580-2048002 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT257506 WP_003088112.1 NZ_CP104301:c2049223-2048669 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References