Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 2048002..2049223 | Replicon | chromosome |
Accession | NZ_CP104301 | ||
Organism | Pseudomonas aeruginosa strain PLL01 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | N4Q74_RS09730 | Protein ID | WP_003114949.1 |
Coordinates | 2048002..2048580 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | N4Q74_RS09735 | Protein ID | WP_003088112.1 |
Coordinates | 2048669..2049223 (-) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N4Q74_RS09715 | 2043279..2044556 | + | 1278 | WP_003102743.1 | TolC family protein | - |
N4Q74_RS09720 | 2044546..2046717 | + | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
N4Q74_RS09725 | 2046707..2047894 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
N4Q74_RS09730 | 2048002..2048580 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
N4Q74_RS09735 | 2048669..2049223 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
N4Q74_RS09740 | 2049381..2051576 | - | 2196 | WP_003114948.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
N4Q74_RS09745 | 2051581..2052042 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
N4Q74_RS09750 | 2052373..2052696 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
N4Q74_RS09755 | 2052709..2053107 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
N4Q74_RS09760 | 2053104..2053655 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T257506 WP_003114949.1 NZ_CP104301:c2048580-2048002 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT257506 WP_003088112.1 NZ_CP104301:c2049223-2048669 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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