Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4043325..4044007 Replicon chromosome
Accession NZ_CP104297
Organism Acinetobacter baumannii strain ZHOU

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N2K92_RS19210 Protein ID WP_000009390.1
Coordinates 4043828..4044007 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1S2G1M8
Locus tag N2K92_RS19205 Protein ID WP_000878688.1
Coordinates 4043325..4043738 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K92_RS19170 (N2K92_19185) 4038640..4039860 + 1221 WP_002067802.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
N2K92_RS19175 (N2K92_19190) 4040007..4041071 + 1065 WP_001278262.1 quinolinate synthase NadA -
N2K92_RS19200 (N2K92_19215) 4042202..4043056 + 855 WP_071211545.1 SH3 domain-containing protein -
N2K92_RS19205 (N2K92_19220) 4043325..4043738 - 414 WP_000878688.1 hypothetical protein Antitoxin
N2K92_RS19210 (N2K92_19225) 4043828..4044007 - 180 WP_000009390.1 type II toxin-antitoxin system HicA family toxin Toxin
N2K92_RS19215 (N2K92_19230) 4044124..4044339 - 216 WP_071211544.1 hypothetical protein -
N2K92_RS19220 (N2K92_19235) 4044349..4045398 - 1050 WP_062936692.1 phage portal protein -
N2K92_RS19225 (N2K92_19240) 4045395..4047173 - 1779 WP_071211543.1 terminase family protein -
N2K92_RS19230 (N2K92_19245) 4047351..4048211 + 861 WP_071211542.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4043325..4055981 12656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(10-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6799.11 Da        Isoelectric Point: 11.1422

>T257502 WP_000009390.1 NZ_CP104297:c4044007-4043828 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Download         Length: 180 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15511.84 Da        Isoelectric Point: 5.2905

>AT257502 WP_000878688.1 NZ_CP104297:c4043738-4043325 [Acinetobacter baumannii]
MKYYVSIVQEEGAYIVSSRDLPLLNSVGYTLEEALSEALDGIETTFEIYMDERKAIPLPSKGKKDEYEIHLPVRVAAKVR
LYNEMISQDVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFHALGKDLDIVVA

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2G1M8

References