Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 106415..107998 Replicon chromosome
Accession NZ_CP104292
Organism Stenotrophomonas maltophilia strain ACYCe.8N

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K7573_RS00440 Protein ID WP_049459435.1
Coordinates 106415..107737 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K7573_RS00445 Protein ID WP_005407534.1
Coordinates 107741..107998 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7573_RS00425 (K7573_00425) 101815..103449 - 1635 WP_005407530.1 TldD/PmbA family protein -
K7573_RS00430 (K7573_00430) 103480..105111 - 1632 WP_172711839.1 TldD/PmbA family protein -
K7573_RS00435 (K7573_00435) 105800..106414 + 615 WP_227843347.1 DUF938 domain-containing protein -
K7573_RS00440 (K7573_00440) 106415..107737 - 1323 WP_049459435.1 type II toxin-antitoxin system HipA family toxin Toxin
K7573_RS00445 (K7573_00445) 107741..107998 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
K7573_RS00450 (K7573_00450) 108160..111846 - 3687 WP_049459434.1 indolepyruvate ferredoxin oxidoreductase family protein -
K7573_RS00455 (K7573_00455) 112018..112653 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49069.93 Da        Isoelectric Point: 6.6866

>T257495 WP_049459435.1 NZ_CP104292:c107737-106415 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGQWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGWGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT257495 WP_005407534.1 NZ_CP104292:c107998-107741 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References