Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 102517..104100 Replicon chromosome
Accession NZ_CP104288
Organism Stenotrophomonas maltophilia strain ACYCa.2H

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K7568_RS00445 Protein ID WP_038646246.1
Coordinates 102517..103839 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K7568_RS00450 Protein ID WP_005407534.1
Coordinates 103843..104100 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7568_RS00430 (K7568_00430) 97923..99557 - 1635 WP_227860091.1 TldD/PmbA family protein -
K7568_RS00435 (K7568_00435) 99588..101219 - 1632 WP_043034903.1 TldD/PmbA family protein -
K7568_RS00440 (K7568_00440) 101902..102516 + 615 WP_043034904.1 DUF938 domain-containing protein -
K7568_RS00445 (K7568_00445) 102517..103839 - 1323 WP_038646246.1 type II toxin-antitoxin system HipA family toxin Toxin
K7568_RS00450 (K7568_00450) 103843..104100 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
K7568_RS00455 (K7568_00455) 104262..107948 - 3687 WP_043034908.1 indolepyruvate ferredoxin oxidoreductase family protein -
K7568_RS00460 (K7568_00460) 108120..108755 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49039.94 Da        Isoelectric Point: 6.9606

>T257489 WP_038646246.1 NZ_CP104288:c103839-102517 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT257489 WP_005407534.1 NZ_CP104288:c104100-103843 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References