Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 272345..272993 Replicon chromosome
Accession NZ_CP104287
Organism Stenotrophomonas maltophilia strain ACYCb.1K

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K7567_RS01190 Protein ID WP_111097688.1
Coordinates 272345..272632 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0U5HHQ5
Locus tag K7567_RS01195 Protein ID WP_058979789.1
Coordinates 272691..272993 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7567_RS01160 (K7567_01160) 268287..269078 - 792 WP_206621621.1 zinc-dependent peptidase -
K7567_RS01165 (K7567_01165) 269045..269323 - 279 WP_005411956.1 hypothetical protein -
K7567_RS01170 (K7567_01170) 269468..270436 + 969 WP_227854337.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
K7567_RS01175 (K7567_01175) 270433..271164 + 732 WP_019661840.1 type III pantothenate kinase -
K7567_RS01180 (K7567_01180) 271174..272022 + 849 WP_227854336.1 SPOR domain-containing protein -
K7567_RS01190 (K7567_01190) 272345..272632 + 288 WP_111097688.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7567_RS01195 (K7567_01195) 272691..272993 + 303 WP_058979789.1 putative addiction module antidote protein Antitoxin
K7567_RS01200 (K7567_01200) 273051..273374 - 324 WP_062606011.1 hypothetical protein -
K7567_RS01205 (K7567_01205) 273455..273862 - 408 WP_134729679.1 hypothetical protein -
K7567_RS01210 (K7567_01210) 274459..275229 + 771 WP_188250544.1 DUF3011 domain-containing protein -
K7567_RS01215 (K7567_01215) 275254..275601 - 348 WP_057503835.1 hypothetical protein -
K7567_RS01220 (K7567_01220) 275733..276653 + 921 WP_227854335.1 arginase -
K7567_RS01225 (K7567_01225) 276816..276953 + 138 WP_019661832.1 entericidin A/B family lipoprotein -
K7567_RS01230 (K7567_01230) 277156..277377 + 222 WP_019661831.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10804.44 Da        Isoelectric Point: 11.3617

>T257488 WP_111097688.1 NZ_CP104287:272345-272632 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRRLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QHRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10694.26 Da        Isoelectric Point: 8.0343

>AT257488 WP_058979789.1 NZ_CP104287:272691-272993 [Stenotrophomonas maltophilia]
MATKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5HHQ5

References