Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4697526..4698142 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N2K86_RS22200 Protein ID WP_260659992.1
Coordinates 4697526..4697897 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N2K86_RS22205 Protein ID WP_010436846.1
Coordinates 4697900..4698142 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS22185 (N2K86_22185) 4695026..4695928 + 903 WP_152082874.1 formate dehydrogenase subunit beta -
N2K86_RS22190 (N2K86_22190) 4695925..4696560 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
N2K86_RS22195 (N2K86_22195) 4696557..4697486 + 930 WP_260659991.1 formate dehydrogenase accessory protein FdhE -
N2K86_RS22200 (N2K86_22200) 4697526..4697897 - 372 WP_260659992.1 type II toxin-antitoxin system VapC family toxin Toxin
N2K86_RS22205 (N2K86_22205) 4697900..4698142 - 243 WP_010436846.1 ribbon-helix-helix protein, CopG family Antitoxin
N2K86_RS22210 (N2K86_22210) 4698342..4699259 + 918 WP_260659993.1 alpha/beta hydrolase -
N2K86_RS22215 (N2K86_22215) 4699272..4700213 - 942 WP_260659994.1 fatty acid biosynthesis protein FabY -
N2K86_RS22220 (N2K86_22220) 4700258..4700695 - 438 WP_108417975.1 D-aminoacyl-tRNA deacylase -
N2K86_RS22225 (N2K86_22225) 4700692..4701573 - 882 WP_010436837.1 virulence factor BrkB family protein -
N2K86_RS22230 (N2K86_22230) 4701567..4702166 - 600 WP_010436834.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13743.91 Da        Isoelectric Point: 6.9686

>T257486 WP_260659992.1 NZ_CP104285:c4697897-4697526 [Enterobacter mori]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIIDVTREIAERSVLLR
ERHGMKLPDAIILATAQCRNCPLISRNTRDFQGITGVVSPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9455.65 Da        Isoelectric Point: 4.2803

>AT257486 WP_010436846.1 NZ_CP104285:c4698142-4697900 [Enterobacter mori]
MSLLADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References