Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4570185..4570792 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag N2K86_RS21625 Protein ID WP_071993467.1
Coordinates 4570607..4570792 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N2K86_RS21620 Protein ID WP_260659923.1
Coordinates 4570185..4570592 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS21605 (N2K86_21605) 4565539..4566939 + 1401 WP_260659920.1 MFS transporter -
N2K86_RS21610 (N2K86_21610) 4566950..4568899 + 1950 WP_260659921.1 glycoside hydrolase family 127 protein -
N2K86_RS21615 (N2K86_21615) 4569105..4570181 + 1077 WP_260659922.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
N2K86_RS21620 (N2K86_21620) 4570185..4570592 - 408 WP_260659923.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N2K86_RS21625 (N2K86_21625) 4570607..4570792 - 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
N2K86_RS21630 (N2K86_21630) 4571002..4571742 - 741 WP_260659924.1 MipA/OmpV family protein -
N2K86_RS21635 (N2K86_21635) 4571860..4572825 + 966 WP_260659925.1 LysR family transcriptional regulator -
N2K86_RS21640 (N2K86_21640) 4572822..4574360 - 1539 WP_260659926.1 aldehyde dehydrogenase family protein -
N2K86_RS21645 (N2K86_21645) 4574526..4575410 + 885 WP_260659927.1 ROK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T257485 WP_071993467.1 NZ_CP104285:c4570792-4570607 [Enterobacter mori]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15025.73 Da        Isoelectric Point: 4.3197

>AT257485 WP_260659923.1 NZ_CP104285:c4570592-4570185 [Enterobacter mori]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTSHFEALFELDDALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSYVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure

References