Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1055719..1056339 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag N2K86_RS04990 Protein ID WP_010428174.1
Coordinates 1055719..1055937 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag N2K86_RS04995 Protein ID WP_008499288.1
Coordinates 1055965..1056339 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS04960 (N2K86_04960) 1051728..1051988 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
N2K86_RS04965 (N2K86_04965) 1051991..1052131 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N2K86_RS04970 (N2K86_04970) 1052128..1052838 - 711 WP_260660673.1 GNAT family protein -
N2K86_RS04975 (N2K86_04975) 1052940..1054400 + 1461 WP_260660674.1 PLP-dependent aminotransferase family protein -
N2K86_RS04980 (N2K86_04980) 1054372..1054839 - 468 WP_042714806.1 YlaC family protein -
N2K86_RS04985 (N2K86_04985) 1054958..1055509 - 552 WP_260660675.1 maltose O-acetyltransferase -
N2K86_RS04990 (N2K86_04990) 1055719..1055937 - 219 WP_010428174.1 HHA domain-containing protein Toxin
N2K86_RS04995 (N2K86_04995) 1055965..1056339 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
N2K86_RS05000 (N2K86_05000) 1056856..1059993 - 3138 WP_260660676.1 multidrug efflux RND transporter permease subunit AcrB -
N2K86_RS05005 (N2K86_05005) 1060016..1061209 - 1194 WP_260660677.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T257476 WP_010428174.1 NZ_CP104285:c1055937-1055719 [Enterobacter mori]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT257476 WP_008499288.1 NZ_CP104285:c1056339-1055965 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References