Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 72229..72891 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N2K86_RS00355 Protein ID WP_260660082.1
Coordinates 72493..72891 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N2K86_RS00350 Protein ID WP_216358243.1
Coordinates 72229..72489 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS00325 (N2K86_00325) 67444..68565 - 1122 WP_260660077.1 efflux RND transporter periplasmic adaptor subunit -
N2K86_RS00330 (N2K86_00330) 68714..69283 - 570 WP_260660078.1 TetR/AcrR family transcriptional regulator -
N2K86_RS00335 (N2K86_00335) 69470..69889 + 420 WP_260660079.1 GNAT family N-acetyltransferase -
N2K86_RS00340 (N2K86_00340) 69886..70533 - 648 WP_260660080.1 TetR/AcrR family transcriptional regulator -
N2K86_RS00345 (N2K86_00345) 70612..72111 + 1500 WP_260660081.1 MDR family MFS transporter -
N2K86_RS00350 (N2K86_00350) 72229..72489 + 261 WP_216358243.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
N2K86_RS00355 (N2K86_00355) 72493..72891 + 399 WP_260660082.1 type II toxin-antitoxin system VapC family toxin Toxin
N2K86_RS00360 (N2K86_00360) 73080..73880 + 801 WP_260660083.1 lipoprotein NlpA -
N2K86_RS00365 (N2K86_00365) 74003..74782 + 780 WP_260660084.1 MBL fold metallo-hydrolase -
N2K86_RS00370 (N2K86_00370) 74808..75761 + 954 WP_260660085.1 helix-turn-helix domain-containing protein -
N2K86_RS00375 (N2K86_00375) 75790..76878 - 1089 WP_260660086.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14784.03 Da        Isoelectric Point: 6.3267

>T257474 WP_260660082.1 NZ_CP104285:72493-72891 [Enterobacter mori]
MLHMLDTNIVSHLVRQHPEVLNQYSRIAPEKMCISSVTEAELLYGVAKKQNNQLHKTIVEFLKTITICDWDSEAAAAYGE
LRAVMEKKGKVMGDLDQLIAAHAISRGTTIVTNDRAFGMVQDLRIEDWTTAA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10062.36 Da        Isoelectric Point: 9.6539

>AT257474 WP_216358243.1 NZ_CP104285:72229-72489 [Enterobacter mori]
MERTAKLIKKGRKQAVVLPAEFAFDTESVYIRRDDEGNVVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYSTR
DPLEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References