Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4465498..4466114 Replicon chromosome
Accession NZ_CP104284
Organism Enterobacter hormaechei subsp. steigerwaltii strain JT.WLB1A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N2K85_RS20985 Protein ID WP_077266491.1
Coordinates 4465498..4465869 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag N2K85_RS20990 Protein ID WP_015569912.1
Coordinates 4465872..4466114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K85_RS20970 (N2K85_20970) 4462998..4463900 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
N2K85_RS20975 (N2K85_20975) 4463897..4464532 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
N2K85_RS20980 (N2K85_20980) 4464529..4465458 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
N2K85_RS20985 (N2K85_20985) 4465498..4465869 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
N2K85_RS20990 (N2K85_20990) 4465872..4466114 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
N2K85_RS20995 (N2K85_20995) 4466313..4467233 + 921 WP_063136781.1 alpha/beta hydrolase -
N2K85_RS21000 (N2K85_21000) 4467242..4468183 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
N2K85_RS21005 (N2K85_21005) 4468228..4468665 - 438 WP_045348649.1 D-aminoacyl-tRNA deacylase -
N2K85_RS21010 (N2K85_21010) 4468662..4469543 - 882 WP_003861949.1 virulence factor BrkB family protein -
N2K85_RS21015 (N2K85_21015) 4469537..4470136 - 600 WP_003861947.1 glucose-1-phosphatase -
N2K85_RS21020 (N2K85_21020) 4470255..4471055 - 801 WP_017382673.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T257472 WP_077266491.1 NZ_CP104284:c4465869-4465498 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT257472 WP_015569912.1 NZ_CP104284:c4466114-4465872 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References